Scientist – RNA Therapeutics Development

Type: Full Time
Location: Gaithersburg, MD

Who we are:

miRecule, Inc. is a rapidly growing biotechnology start-up focused on the development of RNA therapeutics to treat a variety of diseases. miRecule’s DREAmiRTM genomics-based discovery platform is designed to create best-in-class RNA therapies, identifying critical RNA targets for drug development in specific subsets of patients that would benefit from treatment. We then create proprietary chemically modified RNA therapeutics with improved pharmacology, while utilizing antibodies for targeted delivery to the diseased tissue. 

Scientist – RNA Therapeutics Development:

This is a lab-based research role focused on performing of mechanism of action and pharmacology studies on the lead RNA therapy for our Facioscapulohumeral muscular dystrophy (FSHD) program. You will report to the Associate Director.

Essential Duties and Responsibilities: 

  • Planning and execution of in vitro cell culture assays, including cellular toxicity, viability assays, immunoassays, and cell based HTS screening.
  • Generation of clear oral and written communications presenting analysis of experimental data, interpretation of results, and recommendation of next steps.
  • Detailed recording of experimental results in company electronic lab notebook (ELN)
  • Manage relationships with external service providers
  • Collaborate cross-functionally as needed across the miRecule business, operations, and scientific teams.
  • Provide mentorship to Research Associates and other junior team members as required. 


Education and Experience:

  • PhD (or equivalent degree) in Biochemistry, Molecular Biology, Cell Biology, Neurobiology, pharmaceutical sciences, or related disciplines and 0 – 2 years of industry or post-doctoral work OR Master’s degree in Biochemistry, Molecular Biology, Cell Biology, Neurobiology, pharmaceutical sciences, or related disciplines and 5+ years of relevant experience

Essential Skills:

  • Highly experienced at handling, treatment, and transfection of oligonucleotide therapeutics
  • qPCR/dPCR to evaluate on-target and off-target activity of RNA related compounds.
  • Direct experience with evaluating the PK and efficacy of RNA therapeutics including molecular and protein bioanalytic across multiple tissues (biodistribution) to support in vivo POC or toxicology studies.
  • You have an affinity to learning about novel technologies and are willing to contribute to the development thereof.
  • You are intellectually agile and able to thrive in a fast-paced, innovative environment
  • Your work is of high quality, precise and safe

Desired Skills:

  • Fundamental understanding of chemical modifications utilized in oligonucleotide therapies and their impact on potency and toxicity
  • Hands-on experience in leveraging next-generation sequencing (NGS).
  • Experience in presenting data at internal and external meetings with our external partners and CROs to execute on the discovery and development of our lead therapeutic product.
  • Industry experience with knowledge on nucleic acid therapeutics drug development process is desirable

Our culture

At miRecule, we have strived to cultivate a mission-centered culture, enabling the creation of high-quality RNA therapies that can truly change the lives of patients. miRecule employees live the tenets of scientific rigor, teamwork, and mutual respect, allowing us to grow cohesively as a team and help each other to learn and succeed in our pursuit of this important mission. We seek individuals to join our team who resonate with this philosophy both professionally and personally.

Direct Applicants Only – No Agencies Please

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